hmmmmm I’ve been blessed enough to never have to spray my lettuce, so I’ve never tried. But it’s such an effective spray I would definitely try it on just one small section and watch to see if it harms the lettuce. I’m betting if you spray in early evening, as soon as the sun is off the lettuce, and give it plenty of time to work before the sun is beating on the plants again it might do very well. If you try, please let me know!

I love roses but I despise growing them. I tried the first few years of our marriage and gave up on my battle with the Japanese beetles. Never planted roses any other place I’ve lived. So I can’t tell you BUT I know you can try this spray on a small section of any plants and observe it closely for a few days to see if it’s helping or hindering and then go from there… I hope you get it figured out!